Skip to main content
  • European Centre for Environment & Human Health

  • University of Exeter Medical School
  • Menu
  • Search
  • Home
  • About us Our mission and vision
    • Our Mission, Vision and Purpose
    • WHO Collaborating Centre on Natural Environments and Health
    • Peninsula Environment & Human Health Forum
    • Public Engagement
    • Our Mission, Vision and Purpose
    • WHO Collaborating Centre on Natural Environments and Health
    • Peninsula Environment & Human Health Forum
    • Public Engagement
  • Research Learn about our science
  • Impact Informing policy and practice
  • Education Explore our MSc and CPD courses
  • People Meet our staff and students
  • News & blog Updates from people and projects
  • Contact

Do antibiotics in the environment lead to resistance in situ?

Tagged:
  • Antimicrobial Resistance and Microbiology

This 4-year PhD project is aiming to provide robust evidence for a causative relationship between environmental antibiotic concentrations selecting for resistance in situ.

It is funded by the Biotechnology and Biological Sciences Research Council and pharmaceutical company AstraZeneca.

By conducting experiments in synthetic and semi-naturalistic environments, and in single host backgrounds as well as complex bacterial communities, the research is seeking to determine if low antibiotic concentrations select for in situ resistance.

Resistance gene dissemination, fixation and co-selection will be investigated in order to design novel assays that can be used to determine effect concentrations of antibiotics, and implement an environmental risk assessment of antibiotics as micro pollutants.

It’s hoped the study’s findings will have direct implications for future drug development.

Most antibiotics are not fully metabolised by humans or animals. They are also not fully degraded in waste water treatment plants or sewage treatment plants, and natural degradation varies greatly between drugs.

Combined with this persistence, their excessive use as therapeutics, prophylactics and growth promoters has led to their accumulation in the natural environment, albeit at very low concentrations of ng up to ug/l.

Until recently, it was assumed antibiotic resistance would not be selected for in the environment, as environmental concentrations of antibiotics are, on the whole, far below the minimum inhibitory concentration (MIC – the concentration at which bacterial growth is inhibited).

However, Gullberg et al showed the minimal selective concentration to be as low as ng/l, a concentration expected be found in the environment but also greatly below the MIC of the drug tested. Additionally, many studies have found connections between levels of resistance and antibiotic concentrations in a variety of environments.

Do antibiotics in the environment lead to resistance in situ?

Authors

  • Dr Aimee Murray

    Dr Aimee Murray

Related content

Research project

Barriers to entrepreneurship in Cornwall

Exploring the factors preventing low-income individuals in Cornwall from accessing funding and starting new ventures.

Research project

Nature on prescription for mental health

The ‘greENGAGE’ trial will evaluate six weeks in nature for people with anxiety and depression.

Research project

HouseInc – Inclusive housing for marginalised communities

Analysing the interlinked dimensions of housing inequalities, with a focus on marginalised communities in four European countries.

Contact details

European Centre for Environment and Human Health

University of Exeter Medical School

Peter Lanyon Building 12

Penryn, Cornwall, TR10 8RD

  • T: +44 (0) 1326 371859
  • E: ECEHHAdmin@exeter.ac.uk

Sign up to our mailing list

Fill in our form to receive updates on our latest projects, events and publications.

Subscribe

Follow us

  • @ecehh.bsky.social
  • LinkedIn
  • YouTube
  • @ecehh
  • Terms & Conditions
  • Privacy
  • Accessibility

Copyright © 2025. European Centre for Environment & Human Health. All rights reserved.